There is no cure known for completely eliminating Seronegative Arthritis in humans. However, there are various treatments that help people get rid of their symptoms. These treatments are specially designed to moderate the severity of the disease for a long term. The first method involves the consumption of the prescribed dosage of anti-rheumatic drugs (DMARD). These medicines particularly reduce the percentage of the damage in the bone as well as cartilage. These are in fact one of the best medications available for preventing structural damages in the joint. Examples of these drugs are azathioprine ciclosporin (cyclosporine A), D-penicillamine, gold salts, hydroxychloroquine, leflunomide, methotrexate (MTX) etc.

These medicines are accompanied with Anti-Inflammatory and analgesics, if the disease has crossed its moderate form. This potent combination acts towards dissuading further erosions in the bone as well as reducing stiffness in the bones. Apart from the medicines, there are therapies specialized at improving the movement of the joints. Some of the most common therapies are occupational therapy, physiotherapy, podiatry and immunoadsorption therapy. Further, there are interarticular steroid injections that are injected at the painful joint area to enhance its flexibility. At last, mild exercises and activities like swimming, walking etc are most effective towards bettering the mobility of the bones.