The main aim would be identify the cause and eliminating the disease with some of the antibiotics available. One should be clear that the disease is reactive arthritis prior to any medication. It is known that there are various inflammations associated with arthritis in reactive arthritis therefore treatment varies for different inflammations.

 Joint inflammations are usually handled through nonsteroidal anti-inflammatory drugs which include aspirin, tolmethin, sulindac, indomethacin and piroxicam. There are some side effects associated with these drugs like ulceration and also bleeding though taking it along with food would keep these problems away to some extent. For short term inflammation treatments one can use corticosteroids which are available in form of oral medicine or injections. Corticosteroids also help in reducing inflammations of the tendons. For treating persistent reactive arthritis in patients one generally uses Sulfasalazine. It is an effective treatment thou has some side effects like sulfa rash and it affects the bone marrow, suppressing it. Therefore one needs to keep an eye on the blood count while Sulfasalazine is prescribed.

In case of aggressive reactive arthritis, medication prescribed suppresses the human immune system which includes methotrexate, it has a side effects. It affects the liver and the bone marrow. One need keep a check on blood count for the bone marrow and liver toxicity by regularly conducting blood liver test. This is generally avoided as it affects the immune system. Anti inflammatory Eye drops are used for reducing the eye inflammations. Inflammations around the genitals are reduced through medicated creams.